Zocor Drug Interactions

Verapamil
Taking verapamil and Zocor together may cause your body to metabolize the drugs differently than intended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis. If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your Zocor dosage should not exceed 10 mg.
  
Digoxin
Combining digoxin and Zocor appears to slightly increase the levels of digoxin in the blood. When starting Zocor or increasing the Zocor dosage, your healthcare provider may choose to monitor you more closely.
 
Grapefruit Products
It is recommended that people on Zocor not drink grapefruit juice, eat grapefruit, or use grapefruit supplements because doing so can increase the levels of Zocor in the blood. This can increase the chances of developing a serious muscle problem (for example, myopathy or rhabdomyolysis), which can cause the kidneys to stop working (see Zocor and Muscle Pain).
 
If you are being treated with Zocor and want to continue drinking grapefruit juice, talk to your doctor about other cholesterol medications that you can take.
 
(Click Grapefruit Juice and Zocor for more information.)
 

Final Thoughts

There are a number of drugs that can interact with Zocor. It is possible that not all drug interactions were discussed in this article. Therefore, you should talk with your doctor about any specific Zocor interactions that may apply to you.
 
Also, because a number of these medicines can increase the risk of serious muscle problems, if you have any unexplained muscle pain, tenderness, or weakness (especially if it is accompanied by a fever or if you feel ill), contact your healthcare provider immediately.
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