Zocor Drug Interactions

Antifungals
There is a possibility that when Zocor is taken with antifungals, you are at higher risk of developing muscle problems. Zocor should not be taken with itraconazole, ketoconazole, or posaconazole. If you are on Zocor and need to take one of these medications, you will need to stop taking Zocor, at least temporarily.
 
Erythromycin, Clarithromycin, or Telithromycin
Taking Zocor with erythromycin, clarithromycin, or telithromycin is not recommended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis. If you are on Zocor and need to take one of these medications, you will need to stop taking Zocor, at least temporarily.
 
HIV Protease Inhibitors
Taking Zocor and an HIV protease inhibitor is not recommended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis.
 
Ranolazine
Combining ranolazine with Zocor may increase the risk of serious muscle problems (such as myopathy or rhabdomyolysis). If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your dosage of Zocor should not exceed 20 mg.
   
Nefazodone
Taking Zocor and nefazodone is not recommended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis.
  
Amiodarone
Taking amiodarone and Zocor together may cause your body to metabolize the medicines differently than intended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis. If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your Zocor dosage should not exceed 20 mg.
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Zocor Medicine

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