Zocor Drug Interactions

Zocor Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Zocor is combined with any of the drugs listed above.
 
Amlodipine
Combining amlodipine with Zocor may increase the risk of serious muscle problems (such as myopathy or rhabdomyolysis). If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your dosage of Zocor should not exceed 20 mg.
 
Cobicistat
The risk of serious side effects (including myopathy or rhabdomyolysis) is increased by combining Zocor with cobicistat-containing medications, such as Stribild. In general, these medications should not be taken together.
   
Cyclosporine
Taking cyclosporine and Zocor together is not recommended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis.
 
Danazol
Taking danazol and Zocor together is not recommended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis.
 
Diltiazem
Combining diltiazem with Zocor may increase the risk of serious muscle problems (such as myopathy or rhabdomyolysis). If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your dosage of Zocor should not exceed 10 mg.
 
Lomitapide
Lomitapide can increase the level of Zocor in your bloodstream. If you are taking lomitapide, the recommended maximum Zocor dosage is 20 mg a day, or 40 mg a day for people who were previously taking Zocor 80 mg daily before starting lomitapide.
  
Warfarin
If you are taking both Zocor and warfarin, your body may metabolize the medicines differently than intended. When starting Zocor therapy and/or changing the Zocor dosage, your healthcare provider may choose to monitor your INR and prothrombin time more closely and make any necessary adjustments. Prothrombin time and INR are tests used to measure how well your blood is clotting.
 
Gemfibrozil
Taking gemfibrozil and Zocor together is not recommended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis.
  
Niacin
Both niacin and Zocor alone can increase the chances of developing serious muscle problems. Therefore, it is thought that combining these medicines may cause an even greater risk. If you are taking both Zocor and niacin, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments (see Niacin and Zocor). This is particularly important for people of Chinese descent, as studies have suggested that Chinese people may be at a higher risk for problems when combining niacin and Zocor.
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