Zetia Uses

How Does Zetia Work?

Zetia is part of a class of drugs called cholesterol absorption inhibitors. As the name implies, Zetia blocks the absorption of cholesterol from the intestines into the blood. This results in less cholesterol entering the body. It is unique in that it works just at the "brush border" of the small intestine. Because less cholesterol is delivered from the digestive tract to the liver (which depletes the liver's stores of cholesterol), the liver reacts by taking cholesterol out from the blood, helping to reduce cholesterol levels in the blood.
The effects of Zetia also cause decreases in the following forms of cholesterol and fats:
Zetia has little effect on HDL cholesterol (good cholesterol) by itself.

Uses of Zetia in Children

Zetia has been studied for the treatment of heterozygous familial hypercholesterolemia in boys age ten and older and girls age ten and older who had already started getting their periods. It has not been studied in children under ten years old or in girls of any age that have not started their periods yet.
Zetia appeared to be safe and effective for such use, whether used alone or in combination with simvastatin. However, it is not specifically approved for use in this age group. Talk with your child's healthcare provider about the risks and benefits of using Zetia in children.

Is Zetia Used for Off-Label Reasons?

On occasion, your healthcare provider may recommend Zetia for treating something other than the conditions listed in this article. This is called an "off-label" use. At this time, there are no known off-label uses for Zetia.
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