• There are certain other medications that Zetia can interact with (see Zetia Drug Interactions).
   
• Cholesterol-reducing medications have been known to cause an increase in liver enzymes. Therefore, it is recommended that you have a blood test that looks at your liver function before starting Zetia and 12 weeks after treatment has started.
   
• In rare cases, people taking Zetia may develop serious problems in their muscles. These problems can lead to life-threatening complications. Therefore, make sure to contact your healthcare provider immediately if you experience any muscle pain, weakness, or tenderness, especially if it is accompanied by a fever or feeling of illness (see Zetia and Muscle Pain).
   
• Zetia is a pregnancy Category C medicine, meaning that it could potentially cause harm to your unborn child. If you are pregnant, you should take Zetia only if its benefits outweigh the possible risk to your unborn child. If you are taking a statin in conjunction with Zetia, it should be stopped if you are pregnant. Prior to taking Zetia, make sure to let your healthcare provider know if you are pregnant or thinking of becoming pregnant.
   
• It is not known whether Zetia is excreted in breast milk. If you are breastfeeding and taking Zetia, talk with your healthcare provider about whether you should continue the medicine.
   

• You are allergic to Zetia or any component of Zetia or ezetimibe. Your healthcare provider or pharmacist has a list of the inactive ingredients.
   
• You have active liver disease or unexplained high liver enzymes.