Zetia Drug Interactions

Other Fibrates
With the exception of fenofibrate, other fibrates have not been adequately studied in combination with Zetia (this includes gemfibrozil). Taking Zetia with other fibrates is not yet routinely recommended.
 
Cholestyramine (Prevalite, Questran, Questran Light, LoCholest)
Taking cholestyramine and Zetia together may cause a decrease of Zetia in the blood, which can affect its ability to lower cholesterol. It is recommended that you take Zetia either two hours before or four hours after your cholestyramine dose.
 
Colestipol (Colestid)
Taking colestipol with Zetia may cause a decrease of Zetia in the blood and affect its ability to lower cholesterol. It is recommended that you take Zetia either two hours before or four hours after your colestipol dose.
 
Colesevelam (WelChol)
Taking both WelChol and Zetia may cause a decrease of Zetia in the blood, which can affect its ability to lower cholesterol. It is recommended that you take Zetia either two hours before or four hours after your colesevelam dose.
 
Warfarin
If you are taking Zetia simultaneously with warfarin, your body may metabolize the medicines differently than intended. When starting Zetia therapy and/or changing your Zetia dosage, your healthcare provider may choose to monitor your prothrombin time or INR more closely and make any necessary adjustments. Prothrombin time and INR are tests used to measure how well your blood is clotting.
 
Cyclosporine
Taking cyclosporine in conjunction with Zetia may cause your body to metabolize both medicines differently than intended and cause significant reactions, including increasing the risk of developing myopathy (a potentially serious muscle problem). Your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments.
 
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Cholesterol Drug Zetia

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