Other Fibrates
With the exception of
fenofibrate, other fibrates have not been studied in combination with
Zetia (this includes
gemfibrozil). Taking Zetia with other fibrates is not recommended.
Cholestyramine (Prevalite, Questran, Questran Light, LoCholest)
Taking
cholestyramine and Zetia together may cause a decrease of Zetia in the blood, which can affect its ability to
lower cholesterol. It is recommended that you take cholestyramine either two hours before or four hours after your Zetia dose.
Colestipol (Colestid)
Taking
colestipol with Zetia may cause a decrease of Zetia in the blood and affect its ability to lower
cholesterol. It is recommended that you take colestipol either two hours before or four hours after your Zetia dose.
Colesevelam (WelChol)
Taking both
WelChol and Zetia may cause a decrease of Zetia in the blood, which can affect its ability to lower cholesterol. It is recommended that you take WelChol either two hours before or four hours after your Zetia dose.
Warfarin
If you are taking Zetia simultaneously with warfarin, your body may metabolize the medicines differently than intended. When starting Zetia therapy and/or changing your
Zetia dosage, your healthcare provider may choose to monitor your prothrombin time or INR more closely and make any necessary adjustments. Prothrombin time and INR are tests used to measure how well your blood is clotting.
Cyclosporine
Taking cyclosporine in conjunction with Zetia may cause your body to metabolize both medicines differently than intended and cause significant reactions, including increasing the risk of developing myopathy (a potentially serious muscle problem). Your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments.
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