WelChol Drug Interactions
There are several potential WelChol drug interactions to be aware of. For example, if you are taking WelChol at the same time as you are taking certain other drugs, such as oral contraceptives, warfarin, or vitamin K products, WelChol can decrease the absorption of these drugs into the body and thereby lower their effectiveness. You may need to separate doses by four hours to avoid WelChol drug interactions.
WelChol® (colesevelam hydrochloride) has the potential to interact with a number of other medications. Medicines that can cause WelChol drug interactions include:
- Certain vitamins (vitamin A, D, E, and K)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Glimepiride (Amaryl®) or combination drugs that contain glimepiride (Avandaryl®, Duetact®)
- Glyburide (DiaBeta®, Glynase®, Micronase®)
- Levothyroxine (Levothroid®, Levoxyl®, Synthroid®, Tirosint®, Unithroid®)
- Metformin ER (Glucophage XR®, Glutametz®, and Fortamet®)
- Olmesartan (Benicar®) or combination drugs that contain olmesartan (Benicar HCT®, AZOR®)
- Oral contraceptives (birth control pills)
- Phenytoin (Dilantin®, Phenytek®)
- Warfarin (Coumadin®, Jantoven®).
These are just the known interactions with WelChol. Because WelChol has the potential to bind with and decrease the absorption of many drugs, talk with your healthcare provider about specific interactions that may be important in your situation. It is a good idea to take any medication that is important (such as an arrhythmia medication) at least four hours before a dose of WelChol.