Potential Vytorin drug interactions that can lead to unexpected results include cyclosporine, HIV protease inhibitors, niacin, and grapefruit juice or products. When certain medications are taken in conjunction with Vytorin, your body metabolizes the drugs differently than intended. When this happens, potentially dangerous Vytorin drug interactions can occur, including an increased risk for developing serious muscle problems, such as myopathy or rhabdomyolysis.
Grapefruit juice and grapefruit products, including supplements.
Some of these drug interactions with Vytorin may increase your risk for developing serious muscle problems (see Vytorin and Muscle Pain). If you are taking Vytorin and experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by a fever or you feel ill, it is important to contact your healthcare provider immediately.