Vytorin Drug Interactions

Protease Inhibitors
Vytorin and an HIV protease inhibitor should not be combined. This can cause significant reactions, including increasing the risk of developing serious muscle problems, such as myopathy or rhabdomyolysis.
 
Nefazodone
Taking Vytorin with nefazodone is not recommended, as your body may metabolize the medicines differently than intended. This can cause significant reactions, including increasing the risk of developing serious muscle problems, such as myopathy or rhabdomyolysis.
 
Ranolazine
Combining ranolazine with Vytorin may increase the risk of serious muscle problems (such as myopathy or rhabdomyolysis). If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your dosage of Vytorin should not exceed 10/20 mg daily.
  
Verapamil
Combining verapamil and Vytorin may cause your body to metabolize the drugs differently than intended. This can cause significant reactions, including increasing the risk of developing serious muscle problems (myopathy or rhabdomyolysis). If you are taking both of these medicines, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your Vytorin dosage should not exceed 10/10 mg.
 
Warfarin
Vytorin may increase the risk of bleeding due to warfarin. When starting or stopping Vytorin therapy and/or changing the dosage, your healthcare provider may choose to monitor your INR and prothrombin time more closely and make any necessary adjustments. Prothrombin time and INR are tests used to measure how well your blood is clotting.
  

Vytorin Drug Interactions: Final Thoughts

Vytorin can interact with several different products. It is possible that not all Vytorin drug interactions were discussed in this article. Therefore, you should talk with your doctor about specific interactions that may apply to you.
 
Also, because some of these medicines can increase the risk of serious muscle problems, if you have any unexplained muscle pain or weakness (especially with a fever or if you feel ill), contact your healthcare provider immediately.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
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