Vytorin Drug Interactions (Cont.)

 
Amiodarone
Taking amiodarone and Vytorin together may cause your body to metabolize them differently than intended. This can cause significant reactions, including increasing the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments if this is the case. Your Vytorin dosage should not exceed 10/20 mg a day.
 
Verapamil
Taking verapamil and Vytorin simultaneously may cause your body to metabolize the medicines differently than intended. This can cause significant reactions, including increasing the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments. Your Vytorin dosage should not exceed 10/20 mg per day.
 
Digoxin
Taking both digoxin and Vytorin appears to slightly increase the levels of digoxin in the blood. When starting Vytorin or increasing the dosage, your healthcare provider may choose to monitor you more closely.
 
Cholestyramine
Taking cholestyramine and Vytorin together may cause a decrease of Vytorin in the blood, which can affect its ability to lower cholesterol. It is recommended that you take cholestyramine either two hours before your Vytorin dose or four hours after.
 
Colestipol
Taking colestipol and Vytorin together may cause a decrease of Vytorin in the blood and can affect its ability to lower cholesterol. It is recommended that you take colestipol either two hours before or four hours after your Vytorin dose.
 
Colesevelam
If you are taking both Welchol and Vytorin, this may cause a decrease of Vytorin in the blood and affect its ability to lower cholesterol. It is recommended that you take Welchol either two hours before your Vytorin dose or four hours after.
(Vytorin Drug Interactions Continued: Page 5)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;