Vytorin Drug Interactions

More Information on Interactions With Vytorin

The following sections explain in detail the potentially negative interactions that can occur when Vytorin is combined with any of the drugs listed above.
 
Amiodarone
Taking amiodarone and Vytorin together may increase the risk of developing serious muscle problems, such as myopathy or rhabdomyolysis. If you are taking both of these medicines, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your Vytorin dosage should not exceed 10/20 mg once daily.
 
Amlodipine
Combining amlodipine with Vytorin may increase the risk of serious muscle problems (such as myopathy or rhabdomyolysis). If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your dosage of Vytorin should not exceed 10/20 mg once daily.
  
Bile Acid Sequestrants
Bile acid sequestrants can bind to Vytorin in the digestive tract, preventing it from being absorbed into the bloodstream. To avoid this drug interaction, be sure to take Vytorin at least two hours before or four hours after a bile acid sequestrant.
 
Certain Antibiotics and Antifungals
Some antifungals and antibiotics can significantly increase the level of Vytorin in your blood, possibly increasing your risk for side effects, including the risk of developing serious muscle problems, such as myopathy or rhabdomyolysis. Unless your healthcare provider feels that the benefits outweigh the risks, these medicines should not be taken together. Your healthcare provider may recommend that you stop taking Vytorin temporarily while your bacterial or fungal infection is treated. In general, taking Vytorin with erythromycin, telithromycin, or clarithromycin is not recommended at all.
 
Cobicistat
The risk of serious side effects (including myopathy or rhabdomyolysis) is increased by combining Vytorin with cobicistat-containing medications, such as Stribild. In general, these medications should not be taken together.
 
Cyclosporine
Taking cyclosporine and Vytorin together is not recommended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis.
  
Danazol
Combining danazol and Vytorin is not recommended. This can cause significant reactions, including increasing the risk of developing serious muscle problems, such as myopathy or rhabdomyolysis.
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Vytorin Information

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