Vytorin and Muscle Pain

Vytorin Information

Drug Interactions With Vytorin and Muscle Pain

Serious muscle problems are more common when Vytorin is first started or when the dosage is increased. It can, however, happen at any time. There are also certain medicines that, when taken with Vytorin, can increase the risk for serious muscle problems. These medicines include:

Amiodarone (Cordarone^®)
Verapamil (Calan^®, Calan SR^®, Covera-HS^®, Isoptin SR^®, Verelan^®, Verelan PM^®)
Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
Danazol (Danocrine^®)
Fibrates, such as:
- Fenofibrate (Antara^™, Lofibra^™, Tricor^®, Triglide^™)
- Gemfibrozil (Lopid^®)

Niacin (nicotinic acid, Niacor^®, Nicolar^®)
Erythromycin
Clarithromycin (Biaxin^®)
Telithromycin (Ketek^®)
Protease inhibitors, such as:
- Amprenavir (Agenerase^®)
- Atazanavir (Reyataz^®)
- Darunavir (Prezista^™)
- Fosamprenavir (Lexiva^®)
- Indinavir (Crixivan^®)
- Lopinavir and ritonavir (Kaletra^®)
- Nelfinavir (Viracept^®)
- Ritonavir (Norvir^®)
- Saquinavir (Invirase^®)
- Tipranavir (Aptivus^®)

Nefazodone (Serzone^®)
Antifungals, such as:
- Fluconazole (Diflucan^®)
- Itraconazole (Sporanox^®)
- Ketoconazole (Nizoral^®)
- Miconazole
- Posaconazole (Noxafil^®)
- Voriconazole (VFEND^®).

Grapefruit juice and grapefruit products, including grapefruit supplements, should also be avoided (see Grapefruit Juice and Vytorin).

(Vytorin and Muscle Pain Continued: Page 3)
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