Vytorin and Memory Loss
Because memory loss occurs so rarely with Vytorin (probably in less than 1 percent of cases), it is difficult to determine whether the memory loss is actually caused by the medication or by another factor. If you are taking Vytorin and memory loss becomes a problem, notify your healthcare provider. He or she may change your dosage or recommend a different drug.
While most people tolerate Vytorin® (ezetimibe/simvastatin) well, side effects can occur. For people taking Vytorin, memory loss (known medically as amnesia) is a rare but possible side effect, probably occurring in less than 1 percent of people. Because memory loss occurs so infrequently, it is difficult to know whether the memory loss is actually caused by Vytorin or something else.
Memory loss has not been reported in clinical studies of Vytorin specifically. However, simvastatin (one of the components of Vytorin) has been linked to rare cases of memory loss. It is impossible to say with certainty that the medication caused these cases.
Little research has been conducted on Vytorin (or on statins and cholesterol absorption inhibitors in general) and its effect on memory loss and other brain conditions. Furthermore, the research that has been done is conflicting. For example, some studies have shown that people taking statins have a lower chance of developing dementia. Other studies have shown no benefit.
In medical journals, there have been a number of isolated reports of memory loss in people taking statins. However, this number is small compared to the number of people taking statins. Therefore, again, it is difficult to say whether the memory loss is because of statins such as Vytorin or actually caused by something else.