Trilipix

Trilipix is approved to help reduce triglyceride and cholesterol levels. It works by increasing the activity of an enzyme that breaks down triglyceride-rich particles and increases their removal from the body. The medication comes in the form of delayed-release capsules and is typically taken once daily. Possible side effects include headaches, dizziness, and nausea.

What Is Trilipix?

Trilipix (fenofibric acid delayed-release, also known as choline fenofibrate) is a prescription medication used for treating unhealthy cholesterol and triglyceride levels. It works to lower "bad" cholesterol (LDL cholesterol), decrease triglycerides, and increase "good" cholesterol (HDL cholesterol). Unlike other similar medications, Trilipix is approved to be used in combination with statins.
 
(Click Trilipix Uses for more information, including possible off-label uses.)
 

Who Makes This Medication?

Trilipix is made by Abbott Laboratories.
 

How Does Trilipix Work?

Trilipix belongs to a class of drugs known as fibric acid derivatives (also known as fibrates). It works by increasing the activity of an enzyme (lipoprotein lipase) that breaks down triglyceride-rich particles and increases their removal from the body. The medication can also decrease the amount of these particles that are made and released from the liver. Depending on the type of cholesterol problem you have, Trilipix may also:
 

Clinical Effects

In one group of clinical research studies, people taking Trilipix were able to:
 
 
  • Reduce triglyceride levels by 31 percent
  • Reduce LDL cholesterol by 5.1 percent
  • Reduce total cholesterol by 12.4 percent
  • Raise HDL cholesterol by 16.3 percent.
     
Studies have also shown that combining Trilipix with a statin can provide further benefit.
 

When and How Should I Take Trilipix?

Some general considerations for when and how to take this medication include the following:
 
  • This medication comes in the form of a delayed-release capsule. It is taken by mouth once daily.
  • You can take Trilipix with food or on an empty stomach.
  • You must swallow the capsules whole. Do not chew, crush, dissolve, or open them.
  • Be sure to take Trilipix at the same time each day to keep an even level in the blood.
  • For Trilipix to work properly, you have to take it as prescribed. It will not work if you stop taking it.
     

Dosing Information

The dose of Trilipix your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • How you respond to the medication
  • Other medical conditions you may have
  • Other medications you may be currently taking.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 
(Click Trilipix Dosage for more information.)
 

Potential Side Effects

As with any medicine, side effects are possible with Trilipix; however, not everyone who takes it will experience problems. Most people tolerate the drug quite well. If people do develop side effects, in most cases, they are minor, meaning they either require no treatment or can easily be treated by you or a healthcare professional. If side effects do occur, most people do not need to stop taking the medicine.
 
Some of the most common side effects with Trilipix include:
 
Keep in mind that if you experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by a fever or a feeling of illness, it is important to contact your healthcare provider right away. This could be a sign of a serious, life-threatening muscle problem (see Trilipix and Muscle Pain for more information).
 
(Click Trilipix Side Effects to learn more about the potential side effects of this drug, including potentially serious side effects you should report to your healthcare provider.)
 

Drug Interactions With Trilipix

Trilipix may interact with a few other medications (see Trilipix Drug Interactions for more information).
 

What Should I Tell My Healthcare Provider?

If you have any of the following conditions, you should discuss this with your healthcare provider prior to taking Trilipix:
 
  • Gallbladder disease, including gallstones
  • Liver disease, liver failure, or a history of liver disease
  • Kidney disease or kidney failure
  • Any allergies, including allergies to foods, dyes, or preservatives.
     
Let your healthcare provider know if you are:
 
Also, tell your healthcare provider about all other medicines you may be taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
(Click Trilipix Warnings and Precautions for more information, including information on who should not take this medication.)
 

What If I Take an Overdose of Trilipix?

If you happen to overdose on this medicine, seek medical attention immediately (see Trilipix Overdose for more information).
 

How Should This Medicine Be Stored?

Trilipix should be stored at room temperature, away from moisture. Keep this and all medications out of the reach of children.
 

What Should I Do If I Miss a Dose?

If you do not take your dose as scheduled, take it as soon as you remember, unless it is almost time for your next scheduled dose. If it is almost time for your next scheduled dose, skip the one you forgot and take your next dose instead. Do not take a double dose of Trilipix.
 

Available Strengths

Trilipix capsules are available in the following strengths:
 
  • Trilipix 45 mg
  • Trilipix 135 mg.
     

Is There a Generic Version of Trilipix?

This medication is not available in generic form (see Generic Trilipix).
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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