Tricor Drug Interactions

Tricor Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Tricor is combined with any of the drugs listed above. 
Warfarin (Coumadin, Jantoven)
Tricor can increase the anticoagulant effect of warfarin. This means that you are at an increased risk of bleeding if you are taking both Tricor and warfarin. If you are taking these medicines together, your healthcare provider may choose to monitor your INR and prothrombin time more frequently and make any necessary dosing adjustments. Prothrombin time and INR are tests used to measure how well your blood is clotting.
HMG-CoA Reductase Inhibitors (Statins)
The use of Tricor with a statin medication should generally be avoided due to the increased risk of kidney and muscle problems. This combination should be used only if the benefit of further lowering cholesterol levels outweighs the risk.
Colchicine (Colcrys)
Taking Tricor with colchicine may increase the risk of serious problems, including serious breakdown of muscle (rhabdomyolysis). In many cases, though, the benefits of taking Tricor with colchicine will outweigh the possible risks. Discuss the risks and benefits for your particular situation with your healthcare provider.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Cyclosporine can make it harder for Tricor to be eliminated from the body. If you are taking Tricor simultaneously with cyclosporine, you may be at an increased risk of developing kidney problems (especially if you have kidney disease). Your healthcare provider may choose to monitor your progress more closely and make any necessary dosing adjustments.
Bile Acid Sequestrants (Prevalite, Questran, Questran Light, LoCholest, Colestid, WelChol)
Bile acid sequestrants can bind to Tricor in the digestive tract and decrease its absorption into the body. Tricor should be taken at least one hour before or four to six hours after a bile acid sequestrant has been given to avoid this drug interaction.
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