Why Take Statins in the Evening?
Some (but not all) statin medications must be taken in the evening. The liver produces the most cholesterol in the middle of the night (in the early morning hours). Therefore, it is best to take short-acting statins in the evening because taking them early in the day would decrease their effectiveness. This advice applies to the following medications:
- Advicor® (niacin extended-release/lovastatin)
- Altoprev® (lovastatin extended-release)
- Juvisync® (sitagliptin/simvastatin)
- Lescol® (fluvastatin)
- Mevacor® (lovastatin)
- Simcor® (niacin extended-release/simvastatin)
- Vytorin® (ezetimibe/simvastatin)
- Zocor® (simvastatin).
Longer-acting statins can be taken at any time of the day, although you should take them consistently at the same time each day. These longer-acting medications include:
- Caduet® (amlodipine and atorvastatin)
- Crestor® (rosuvastatin)
- Lescol XL (fluvastatin extended-release)
- Lipitor® (atorvastatin)
- Liptruzet™ (ezetimibe/atorvastatin)
- Livalo® (pitavastatin)
- Pravachol® (pravastatin).
(Click Statins for more information on why some statins must be taken in the evening. This article also discusses potential side effects, general dosing guidelines, and what to tell your healthcare provider before beginning treatment.)