Simcor Warnings and Precautions

Some Precautions and Warnings for Simcor

Some precautions and warnings to be aware of include:
  • Rhabdomyolysis (the severe breakdown of muscles) and other serious muscle problems have rarely been reported with Simcor and other statins. You are at greater risk for developing muscle problems, such as rhabdomyolysis, with Simcor if:



  • If you are an alcoholic or drink alcohol frequently, discuss this with your healthcare provider prior to starting Simcor. Alcohol can affect the way the liver works, indirectly affecting the Simcor.
  • Statins (such as simvastatin, one of the components of Simcor) have been known to cause an increase in liver enzymes. Therefore, it is recommended that you have a blood test that looks at your liver function before starting this drug. These tests may also be recommended if the Simcor dosage is changed (see Simcor and Liver Problems).
Previously it had been recommended that people taking statins have routine periodic liver function tests while taking the medication, but this recommendation has been removed, since such monitoring does not help much to detect or prevent such problems. Liver function tests should still be performed if there is any suspicion of liver damage. 
  • Make sure to contact your healthcare provider immediately if you experience any muscle pain, weakness, or tenderness, especially if it is with a fever or if you feel ill (see Simcor and Muscle Pain).
  • Simcor can increase blood sugar in people with diabetes. If you have diabetes, check with your healthcare provider before taking this medication.
  • Simcor can increase the level of uric acid in the blood, which can worsen (and possibly even cause) gout.
  • Simcor must be started at a low dose and increased gradually, in order to avoid intolerable flushing due to the niacin component (see Simcor Dosage and Niacin Flush for more information).
  • Simcor may increase the risk of bleeding, possibly due to decreased blood platelets.
  • Simcor is a pregnancy Category X medicine, meaning that it could potentially cause harm to your unborn child. The safety of Simcor in pregnant women has not been established. If you are pregnant and taking Simcor, talk to your healthcare provider immediately (see Simcor and Pregnancy).
  • If you are nursing, it is not known whether Simcor passes through your milk. Therefore, if you are taking the drug, discuss with your healthcare provider whether to stop nursing or stop taking Simcor.
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