Simcor is a combination medicine of
niacin extended-release and simvastatin. Simvastatin is part of a class of drugs called
statins. It works by blocking a particular enzyme (HMG-CoA reductase) that controls the rate of cholesterol production in the body. This causes the liver to make less cholesterol. It also increases the liver's ability to collect and get rid of
LDL cholesterol.
Niacin, or nicotinic acid, is also used as a cholesterol-lowering medicine. It is not completely understood how niacin works. It probably works in several ways to improve
cholesterol levels. It is thought that niacin works to
increase HDL cholesterol ("good" cholesterol) levels by preventing the liver from removing
HDL from the bloodstream. Additionally, niacin seems to decrease the liver's production of LDL and
VLDL, two types of "bad" cholesterol. Niacin also helps decrease the release of fatty acids (from body fat) into the bloodstream.
Because of the effects of simvastatin and niacin, Simcor can help decrease the following "bad" forms of cholesterol and fats:
- Total cholesterol
- LDL cholesterol
- Apo B cholesterol
- Non-HDL cholesterol
- Triglycerides.
Simcor also increases HDL cholesterol ("good" cholesterol).