Simcor Side Effects

Common Side Effects of Simcor

Simcor has been studied in clinical trials, with hundreds of people having been evaluated. In these studies, side effects were documented and compared to problems that occurred in a similar group of people taking just simvastatin (without the extended-release niacin).
Based on these studies, the most common side effects of Simcor included:
  • Flushing -- in up to 59 percent of people
  • Headache -- up to 4.5 percent
  • Itching -- up to 3.2 percent
  • Nausea -- up to 3.2 percent
  • Back pain -- up to 3.2 percent
  • Diarrhea -- up to 3 percent.

Serious Side Effects

There are several side effects that you should report immediately to your healthcare provider. These include, but are not limited to:
  • Muscle pain, tenderness, or weakness, especially if you also have a fever or feel ill, since these may be signs of serious breakdown of muscle, known as rhabdomyolysis (see Simcor and Muscle Pain)
  • Significant, unexplained changes in the amount of urine you produce (which may be a sign of kidney problems)
  • Signs of liver damage (see Simcor and Liver Problems), such as:


    • Yellowing of the whites of the eyes or skin (jaundice)
    • Upper-right abdominal pain (stomach pain)
    • Dark urine
    • High liver enzymes (found using a blood test)


  • Signs of a stomach ulcer, such as:


    • Severe heartburn
    • Stomach pain
    • Loss of appetite
    • Dizziness
    • Vomiting blood
    • Blood in the stool (seen as dark-colored stools)


  • Easy bruising or bleeding (or bleeding that is slow to stop)
  • Gout
  • High blood sugar (hyperglycemia)
  • Signs of low blood pressure (hypotension), such as lightheadedness, dizziness, or fainting
  • An irregular heart rhythm (arrhythmia)
  • Signs of an allergic reaction, such as:


    • A rash
    • Itching
    • Joint pain
    • Anemia
    • Low white blood cell counts
    • Sensitivity to the sun
    • Fever and chills
    • Flushing
    • A general ill feeling
    • Hives
    • Wheezing or difficulty breathing
    • Swelling of the mouth, tongue, or throat.


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