In one clinical study, people taking Simcor 1000/20 mg once daily were able to, on average, decrease LDL cholesterol by 11.9 percent, decrease triglycerides by 26.5 percent, and increase HDL by 20.7 percent. Generally, the effects of Simcor on cholesterol and triglyceride levels were greater with higher doses of Simcor.
Some general considerations for when and how to take the medication include:
- Your Simcor medication should be taken at bedtime with a low-fat snack.
- Alcohol and hot drinks may worsen flushing symptoms and itchy skin, which are common side effects of Simcor. Alcohol and hot drinks should be avoided close to the time that the medicine is taken.
- Swallow the tablet whole with a glass of water. Do not break, chew, or crush the tablets.
- For Simcor to work properly, you have to take it as prescribed. It will not work if you stop taking it.
It is recommended that people who are on Simcor avoid drinking large quantities of grapefruit juice because it can increase the levels of simvastatin (one of the active ingredients) in the blood. This could increase the risk of developing serious muscle problems. If you want to continue drinking grapefruit juice, talk to your doctor about other cholesterol-lowering medications that you can take.
(Click Simcor and Grapefruit for more information.)
As with any cholesterol medication, you should continue to eat a low-fat, low-cholesterol diet as part of your cholesterol-lowering treatment program.