The usual starting dosage of Simcor for most people is 500/20 mg once a day, taken at bedtime with a low-fat snack. If necessary, your healthcare provider may gradually increase your dose up to a maximum of 2000/40 mg daily. If you are switching from Niaspan, your healthcare provider may recommend that you start with a dose that is higher than normally recommended.
The dosage of Simcor® (niacin extended-release/simvastatin) that your healthcare provider recommends will vary, depending on a number of factors, including:
- How you respond to Simcor
- Other medical conditions you may have
- Other medications you may currently be taking (see Simcor Drug Interactions)
- Your cholesterol goal.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
The recommended starting Simcor dose for most people with high cholesterol is 500/20 mg once a day, taken at bedtime with a low-fat snack.
Your healthcare provider may increase your dose if necessary. This must be done slowly, to minimize liver problems as well as flushing due to the niacin component of the medication. It is recommended to increase the dose no more rapidly than by 500 mg (based on the niacin component) every four weeks. The dosage can also be decreased if Simcor side effects occur. The maximum recommended daily dosage of Simcor is 2000/40 mg (two 1000/20 mg tablets) once daily.
In order to minimize flushing, your healthcare provider may recommend taking aspirin or other similar nonsteroidal anti-inflammatory drugs (NSAIDS), such as ibuprofen. This works best if you take the aspirin or NSAID about 30 minutes before your Simcor dose. Be sure to check with your healthcare provider first, since there may be a reason why you should not take aspirin or an NSAID.
There is no way to take less than 20 mg of the simvastatin component while taking Simcor, since the tablets cannot be split. Therefore, if a lower dosage is recommended in your particular situation, this medication is not a good choice for you.