Pravachol Drug Interactions

More Information on Interactions With Pravachol

The following sections explain in detail the potentially negative interactions that can occur when Pravachol is combined with any of the drugs listed above.

 

Some antifungal medications may slightly increase the level of Pravachol in your blood. There is a possibility that when Pravachol is taken with these medications, you may be at higher risk of developing muscle problems. Unless your healthcare provider feels that the benefits outweigh the risks, these medicines should not be taken together.

 

There is conflicting information about whether cyclosporine can increase the level of Pravachol in your blood (which could cause significant reactions, including increasing the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis). Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments if you take these medications together. A lower starting Pravachol dosage (10 mg daily) is recommended for people taking cyclosporine.

 

Combining erythromycin with other statin medications that are similar to Pravachol has been reported to increase the risk of serious muscle problems, such as myopathy or rhabdomyolysis. It is not clear if this is also a problem with Pravachol. Check with your healthcare provider before taking these medications together.

 

If you are taking Pravachol and a fibrate, you may have an increased risk for serious reactions, including serious muscle problems, such as myopathy or rhabdomyolysis, since both medications can cause such problems when taken individually. The combination of gemfibrozil and Pravachol should be avoided if possible. With the other fibrates, careful monitoring may be required when used in combination with Pravachol.