Cholesterol Home > Zocor Drug Interactions

Among other things, drug interactions with Zocor can change how your body metabolizes the drugs and alter the levels of some drugs in your blood. Verapamil, cyclosporine, and amiodarone can cause negative interactions. Also, Zocor should not be taken with grapefruit juice or grapefruit products, as this may increase the levels of Zocor in your blood, which can increase your risk of developing serious muscle problems.

Drug Interactions With Zocor: An Overview

Zocor® (simvastatin) can potentially interact with a number of other medicines. Some of the substances that can interfere with Zocor include:
  • Antifungals, such as:


    • Ketoconazole (Nizoral®)
    • Itraconazole (Sporanox®)
    • Posaconazole (Noxafil®)



Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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