Cholesterol Home > Simcor

Simcor is a prescription drug approved to treat high cholesterol and triglyceride levels. It is a combination product that contains simvastatin and extended-release niacin, medications that work by preventing the liver from removing HDL ("good" cholesterol) from the bloodstream and blocking a particular enzyme that controls the rate of cholesterol production in the body. The drug comes in tablet form and is generally taken once daily.

What Is Simcor?

Simcor® (niacin extended-release/simvastatin) is a prescription medication used for treating unhealthy triglyceride or cholesterol levels. It contains two different cholesterol medications -- simvastatin (Zocor®) and extended-release niacin (Niaspan®).
 
(Click Simcor Uses for more information, including possible off-label uses.)
 

Who Makes This Medicine?

Simcor is made by Abbott Laboratories.
 

How Does Simcor Work?

Simcor is a combination of extended-release niacin and simvastatin. Niacin, or nicotinic acid, is also used as a cholesterol-lowering medicine. How niacin works is not completely understood. It probably works in several ways to improve cholesterol levels. It is thought that niacin works to increase HDL cholesterol ("good" cholesterol) levels by preventing the liver from removing HDL from the bloodstream. Additionally, niacin seems to decrease the liver's production of LDL and VLDL, two types of "bad" cholesterol. Niacin also helps decrease the release of fatty acids (from body fat) into the bloodstream.
 
Simvastatin is part of a class of drugs called statins. It works by blocking a particular enzyme (HMG-CoA reductase) that controls the rate of cholesterol production in the body. This causes the liver to make less cholesterol. It also increases the liver's ability to collect and get rid of LDL cholesterol.
 
Because of the effects of simvastatin and niacin, Simcor can help decrease the following "bad" forms of cholesterol and fats:
 
  • Total cholesterol
  • LDL cholesterol
  • Apo B cholesterol
  • Non-HDL cholesterol
  • Triglycerides.
     
Simcor also increases HDL cholesterol ("good" cholesterol).
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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