Cholesterol Home > Simcor Drug Interactions

When Simcor is combined with certain antibiotics or antifungal medications, drug interactions may occur. These interactions could increase the level of Simcor in your blood, increasing the risk of side effects, including dangerous side effects such as myopathy or rhabdomyolysis. Other medicines that may cause potentially serious drug interactions with Simcor include digoxin, fibrates, protease inhibitors, and blood pressure medications.

Simcor Interactions: An Introduction

Simcor® (niacin extended-release/simvastatin) is a prescription cholesterol medication. Because it contains two different drugs, it has the potential to interact with quite a few other medications. Some of the medicines that may lead to drug interactions with Simcor include:
 

 

 

 

 

  • Certain antifungals, such as:

 

    • Fluconazole (Diflucan®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Posaconazole (Noxafil®)
    • Voriconazole (VFEND®)

 

 

 

 

 

Some of these drug interactions with Simcor may increase your risk for developing serious muscle problems (see Simcor and Muscle Pain). If you experience unexplained muscle pain, tenderness, or weakness (especially if they are accompanied by a fever or feeling of illness) while taking Simcor, it is important to contact your healthcare provider immediately.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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