Cholesterol Home > Lopid Precautions and Warnings

Lopid has the potential to interact with a number of other drugs, and should not be taken by anyone with severe liver or kidney disease. Other Lopid precautions and warnings include the possibility that this drug may lead to an increase in liver enzymes or contribute to gallstones in some cases. People who have pre-existing gallbladder disease or gallstones should not take this medication.

Lopid: What Should I Tell My Healthcare Provider?

Prior to taking Lopid® (gemfibrozil), you should talk with your healthcare provider if you have:
  • Gallbladder disease or gallstones
  • Kidney disease or kidney failure
  • Liver disease or liver failure
  • Diabetes
  • Heart disease
  • An allergy to Lopid, any other medications, foods, dyes, or preservatives.
It is also important to let your healthcare provider know if you are:
  • Pregnant or planning on becoming pregnant
  • Breastfeeding
  • A frequent user of alcoholic beverages.
Tell your healthcare provider about all the medicines you may currently be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Some Lopid Precautions and Warnings

Some precautions and warnings to be aware while taking Lopid include:
  • Lopid can interact with certain medications (see Lopid Drug Interactions).
  • Lopid can increase the cholesterol content in the bile, leading to gallstones. Your healthcare provider may decide to have you stop taking Lopid if gallstones are found in your body.
  • If you have severe kidney disease, Lopid can make your condition worse. Therefore, it's recommended that you do not take Lopid if you have severe kidney disease. Your healthcare provider should instead consider an alternative cholesterol medicine. If Lopid is necessary, it should be used with extreme caution.
  • Lopid has been known to occasionally cause an increase in liver enzymes. Therefore, it is recommended that you have a blood test that looks at your liver function before starting Lopid and several months after treatment has started. These tests may also be recommended if the Lopid dosage is changed (see Lopid and Liver Problems).
  • Lopid has been associated with the rare but serious condition known as rhabdomyolysis (severe breakdown of muscles). Your risk increases if you are elderly, have kidney disease, or are not being properly treated for hypothyroidism.

Let your healthcare provider know immediately if you experience any muscle pain, tenderness, or weakness, especially if they are accompanied by unexplained tiredness or fever (see Lopid and Muscle Pain).  

  • Lopid has been shown to cause a decrease in certain blood cells at the beginning of therapy. Your healthcare provider may decide to monitor your blood counts more closely during the first 12 months of your treatment.
  • Lopid is considered a pregnancy Category C medicine. This means it has not been studied in pregnant women. However, when studied in animals, it did produce a negative effect on the fetus. If you are pregnant, you should take Lopid only if the benefit outweighs the possible risk to your unborn child. If you become pregnant while taking Lopid, contact your healthcare provider immediately (see Lopid and Pregnancy).
  • If you are nursing, it is not known if Lopid passes through your milk. However, Lopid has been shown to increase the risk of tumors in nursing animals. Therefore, if you are nursing and taking Lopid, it's recommended that you either stop nursing or stop taking Lopid. Your healthcare provider should make this decision.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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