Cholesterol Home > Juvisync

As a combination medicine, Juvisync can help lower cholesterol in people with type 2 diabetes. It comes as a tablet that is taken once daily in the evening. Your specific dosage will depend on several factors, such as how you respond to the medicine and other medications you are taking. Side effects may include headaches, bronchitis, and abdominal (stomach) pain.

In September 2013, Merck & Co, Inc., announced that it would be discontinuing this medication. It is clear that this decision was made for business reasons, not for safety reasons.

What Is Juvisync?

Juvisync® (sitagliptin/simvastatin) is a prescription combination medication. It contains sitagliptin (Januvia®), a type 2 diabetes medication, and simvastatin (Zocor®), a "statin" cholesterol medication.
(Click Juvisync Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medicine?

Juvisync is made by MSD International GmbH for Merck & Co., Inc.

How Does Juvisync Work?

Juvisync is a combination of sitagliptin and simvastatin. Sitagliptin belongs to a class of diabetes medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down incretin hormones.
As a DPP-4 inhibitor, sitagliptin slows down the breakdown of incretin hormones, increasing the level of these hormones in the body. It is this increase in incretin hormones that is responsible for the beneficial actions of sitagliptin, such as increasing insulin production in response to meals and decreasing the amount of glucose (sugar) that the liver produces.
Because incretin hormones are more active in response to higher blood sugar levels (and are less active in response to low blood sugar), the risk of dangerously low blood sugar (hypoglycemia) is low with sitagliptin.
Simvastatin is part of a class of drugs called statins. It works by blocking a particular enzyme (HMG-CoA reductase) that controls the rate of cholesterol production in the body. This causes the liver to make less cholesterol. It also increases the liver's ability to collect and get rid of LDL cholesterol.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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