Many people may wonder what the difference is between Lipitor versus Crestor. While both medications are statins and are effective for lowering cholesterol, there are some differences. Lipitor is known to interact with grapefruit juice, but there are no dietary restrictions for Crestor. One short study showed that Crestor was more effective than Lipitor, but more research is needed to confirm these findings.
Both Crestor and Lipitor belong to a class of drugs called statins (also known as HMG-CoA reductase inhibitors). Statins work by blocking a particular enzyme, HMG-CoA reductase, that controls the rate of cholesterol production in the body. This causes the liver to make less cholesterol. Both medications are very effective for lowering cholesterol.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Crestor [package insert]. Wilmington, DE: AstraZeneca LP;2013 August.
AstraZeneca Pharmaceuticals. First head to head study comparing CRESTOR® and LIPITOR® effects on the treatment of atherosclerosis (1/15/2008). AstraZeneca Web site. Available at: http://www.astrazeneca.com/Pressrelease/5369.aspx. Accessed November 11, 2008.
Lipitor [package insert]. New York, NY: Pfizer, Inc.; 2007 November.
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