Cholesterol Home > Caduet Warnings and Precautions

Before taking Caduet, warnings and precautions for the drug should be reviewed with your healthcare provider. This includes possible side effects, such as increased liver enzymes and muscle problems, as well as conditions to tell your healthcare provider about. For example, Caduet warnings and precautions also extend to women who may be pregnant or breastfeeding and people with liver disease or coronary artery disease.

Caduet: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Caduet® (amlodipine and atorvastatin) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Caduet Warnings and Precautions

Warnings and precautions to be aware of prior to taking Caduet include the following:
  • In general, calcium channel blockers (including amlodipine, one of the components of Caduet) should not be used in people with congestive heart failure (CHF). However, amlodipine does not usually seem to have a negative effect on heart failure.
  • If you have severe coronary artery disease, there is a low possibility that taking Caduet may increase your chances of worsening chest pain or a heart attack when starting Caduet or when increasing your dose.
  • Statins (including atorvastatin, one of the components of Caduet) have been known to cause an increase in liver enzymes, which can be a sign of liver damage. Therefore, healthcare providers typically recommend that you have a blood test to check your liver function before starting Caduet.

Previously it had been recommended that people taking statins have routine periodic liver function tests while taking the medication, but this recommendation has been removed since such monitoring does not help much to detect or prevent such problems. Liver function tests should still be performed if there is any suspicion of liver damage.

  • In one study, atorvastatin (one of the components of Caduet) appeared to increase the risk of a stroke in people who had experienced a stroke or transient ischemic attack (TIA or "mini-stroke") within the previous six months. Talk with your healthcare provider about taking Caduet if you have a history of a stroke or TIA.

  • Rhabdomyolysis (the severe breakdown of muscles) has been reported in rare cases with atorvastatin and other statins. This muscle damage can cause serious kidney damage. You are at greater risk for developing muscle problems with Caduet (and subsequent kidney damage) if you:
    • Have a severe infection
    • Have low blood pressure (hypotension)
    • Have major surgery or experience a major injury
    • Have severe electrolyte or hormonal imbalances
    • Have uncontrolled seizures
    • Are taking certain medications, such as fibrates (Lopid®), niacin, cyclosporine, erythromycin, or antifungal medicines (see Caduet Drug Interactions).
Make sure to contact your healthcare provider immediately if you experience any muscle pain, weakness, or tenderness, especially if it is accompanied by a fever or if you feel ill. 
  • Caduet is considered a pregnancy Category X medication. This means that it is dangerous when used during pregnancy (see Caduet and Pregnancy).
  • It is not known if Caduet passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Caduet and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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