Drug Interactions With Lovastatin

There are a number of drugs that can potentially cause severe side effects or complications when taken with lovastatin. When lovastatin is taken with medicines such as protease inhibitors, antifungals, or niacin, your body may metabolize the drugs differently than intended. For example, certain lovastatin drug interactions can increase your risk for developing serious muscle problems.

Interactions With Lovastatin: An Introduction

 Lovastatin (Mevacor®) may interact with a number of other medications. Some of the medications that may lead to lovastatin drug interactions include:
 
  • Amiodarone (Cordarone®, Pacerone®)
  • Certain antibiotics, such as:
     
 
  • Certain antifungals, such as:
     
    • Fluconazole (Diflucan®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Posaconazole (Noxafil®)
    • Voriconazole (VFEND®)
 
 
 
Some of these drug interactions with lovastatin may increase your risk for developing serious muscle problems (see Mevacor and Muscle Pain). If you experience unexplained muscle pain, tenderness, or weakness while taking lovastatin (especially if you also have a fever or feel ill), it is important to contact your healthcare provider right away.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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