Drug Interactions With Lovastatin
There are a number of drugs that can potentially cause severe side effects or complications when taken with lovastatin. When lovastatin is taken with medicines such as protease inhibitors, antifungals, or niacin, your body may metabolize the drugs differently than intended. For example, certain lovastatin drug interactions can increase your risk for developing serious muscle problems.
Lovastatin (Mevacor®) may interact with a number of other medications. Some of the medications that may lead to lovastatin drug interactions include:
- Amiodarone (Cordarone®, Pacerone®)
- Certain antibiotics, such as:
- Certain antifungals, such as:
- Cobicistat-containing products (such as Stribild®)
- Colchicine (Colcrys®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Danazol (Danocrine®)
- Diltiazem (Cardizem®, Cardizem CD®, Cardizem LA®, Cartia XT®, Dilacor XR®, Dilt-CD®, Diltia XT®, Dilt-XR®, Taztia XT®, Tiazac®)
- Fibrates, such as:
- Grapefruit juice
- Nefazodone (Serzone®)
- Niacin (nicotinic acid, Niacor®, Nicolar®)
- Protease inhibitors, such as:
- Ranolazine (Ranexa®)
- Verapamil (Calan®, Calan SR, Verelan®, Verelan PM, Isoptin®, Covera-HS®)
- Warfarin (Coumadin®, Jantoven®).
Some of these drug interactions with lovastatin may increase your risk for developing serious muscle problems (see Mevacor and Muscle Pain). If you experience unexplained muscle pain, tenderness, or weakness while taking lovastatin (especially if you also have a fever or feel ill), it is important to contact your healthcare provider right away.