Drug Interactions With Lovastatin

More Information on Lovastatin Drug Interactions

The following sections explain in detail the potentially negative interactions that can occur when lovastatin is combined with any of the drugs listed above.
 
Amiodarone
Taking both amiodarone and lovastatin increases the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments. Your lovastatin dosage should not exceed 40 mg per day.
 
Certain Antibiotics
Some antibiotics may increase the level of lovastatin in your blood, increasing the risk of lovastatin side effects, including dangerous side effects such as myopathy or rhabdomyolysis. These medications should not be taken with lovastatin; instead alternative antibiotics should be recommended. If no suitable alternatives are available, you should stop taking lovastatin while taking the antibiotic.
 
Certain Antifungals
Some antifungal medications may increase the level of lovastatin in your blood, increasing the risk of side effects, including dangerous side effects of lovastatin such as myopathy or rhabdomyolysis. These medications should not be taken with lovastatin; instead alternative antifungals should be recommended. If no suitable alternatives are available, you should stop taking lovastatin while taking the antifungal.
 
Cobicistat
The risk of serious side effects (including myopathy or rhabdomyolysis) is increased by combining lovastatin with cobicistat-containing medications, such as Stribild. In general, these medications should not be taken together.
 
Colchicine
There have been a few cases of serious muscle problems, such as myopathy or rhabdomyolysis, in people taking lovastatin with colchicine. Your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments.
  
Cyclosporine
Taking cyclosporine and lovastatin together may increase the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. These medications should not be taken together.
 
Diltiazem
Taking both diltiazem and lovastatin together may increase the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments. If you take diltiazem, the recommended starting lovastatin dosage is 10 mg daily, and the maximum recommended dosage is 20 mg daily.
  
Fibrates
Combining a fibrate with lovastatin increases the risk of serious muscle problems. Combining lovastatin with gemfibrozil should be avoided. Combining lovastatin with other fibrates should be done cautiously with extra monitoring.
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Lovastatin Medicine

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