Lipitor and Muscle Weakness

There is a link between Lipitor and muscle weakness -- muscle weakness is a relatively common side effect seen with Lipitor. Based on data from clinical studies, muscle weakness appears to be most common in people taking Lipitor 40 mg. In most cases, people who experience muscle weakness with Lipitor have no other related symptoms; however, muscle weakness can be a sign of serious muscle problems. If you do develop muscle weakness while taking Lipitor (especially if it occurs with a fever or illness), contact your healthcare provider immediately.

 

Lipitor and Muscle Weakness: An Introduction

While most people tolerate Lipitor® (atorvastatin calcium) well, there are possible Lipitor side effects that can occur. Muscle weakness is one such common side effect of Lipitor. In previous clinical studies, muscle weakness occurred in up to 4 percent of people. It was most common in those taking Lipitor 40 mg and least common in people taking Lipitor 20 mg (0 percent).
 

Muscle Weakness With Lipitor -- What to Watch For

Most people who have muscle weakness while on Lipitor have no other related symptoms.
 However, in less than 1 percent of cases, people develop a serious problem with their muscles while on Lipitor, and muscle weakness can be a symptom of such a serious muscle problem. Two serious muscle problems that are rarely seen in people taking Lipitor are myopathy and rhabdomyolysis. Rhabdomyolysis is very serious because it can cause muscles to break down, which can lead to acute kidney failure, and in some cases, to loss of life.
 
If you develop muscle weakness, tenderness, or pain (especially if you also have a fever or feel ill) while on Lipitor, call your healthcare provider immediately. This could be a sign that you have a serious condition that needs treatment right away.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;