Lipitor and Muscle Weakness: Drug Interactions
Serious muscle problems are more common when people first start taking
Lipitor (or when they begin taking a stronger dosage), but they can happen at any time. There are also certain medicines that can interact with Lipitor and increase the risk for serious muscle problems. These medicines include:
- Antifungals, such as ketoconazole (Nizoral®), fluconazole (Diflucan®), and itraconazole (Sporanox®)
- Clarithromycin (Biaxin®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Erythromycin (Ery-Tab®)
- Fibrates, such as:
Lipitor and Muscle Weakness: Final Thoughts
For people taking Lipitor, muscle weakness is a common problem, especially when first starting the medication or when the
Lipitor dosage is increased. Unfortunately, it is not possible for your healthcare provider to know whether you will develop this side effect if you have never taken Lipitor. Therefore, if muscle weakness becomes a problem while taking Lipitor, talk with your healthcare provider. He or she may be able to give you other suggestions for dealing with muscle weakness. If the muscle weakness continues, he or she may recommend adjusting the Lipitor dosage or switching to another
cholesterol medication.
Also, if muscle weakness, pain, or tenderness occurs with a fever or feeling of sickness, it can mean there is a serious problem. Call your healthcare provider immediately.