Lipitor® (atorvastatincalcium) can cause negative interactions with several substances, including grapefruit. When Lipitor and grapefruit are combined, the grapefruit interferes with an enzyme in the digestive tract that breaks down Lipitor. As a result, this interaction can significantly increase the levels of Lipitor in your blood. Also, this can increase your risk of developing serious muscle problems, such as myopathy or rhabdomyolysis, which can lead to kidney failure and other life-threatening complications.
(Click Lipitor and Grapefruit for more information on how using certain grapefruit products can interfere with the effects of Lipitor, possibly causing serious complications. You can also click any of the links in the box to the right for specific information.)