Lescol Side Effects

Common Side Effects of Lescol

Lescol has been studied extensively in clinical trials, with thousands of people having been evaluated. In these studies, side effects are always documented and compared to side effects that occur in a similar group of people taking a placebo (a "sugar pill" with no active ingredients). This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group taking the placebo.
 
Based on these studies, the most common Lescol side effects included:
 
  • Headache -- in up to 8.9 percent of people
  • Indigestion or heartburn -- up to 7.9 percent
  • Muscle pain, known medically as myalgia -- up to 5 percent (see Lescol and Muscle Pain)
  • Diarrhea -- up to 4.9 percent
  • Abdominal pain (stomach pain) -- up to 4.9 percent
  • Nausea -- up to 3.2 percent.
     
Other common side effects (occurring in 2 to 3 percent of people) included:
 

Side Effects to Report

Some side effects with Lescol, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
  • Signs of liver damage, such as:
 
 
  • Muscle pain, tenderness, or weakness, especially if you also have a fever or feel ill (which may be signs of serious breakdown of muscle, known as rhabdomyolysis)
 
 
  • Significant, unexplained changes in the amount of urine you produce (which may be a sign of kidney problems)
 
  • Signs of an allergic reaction, such as:
     
    • A rash
    • Itching
    • Hives
    • Wheezing or difficulty breathing
    • Swelling of the mouth, tongue, or throat.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
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