Lescol Drug Interactions

Diclofenac (Cataflam, Voltaren)
Taking diclofenac and Lescol together may cause the levels of diclofenac in the blood to be significantly higher than intended. Your healthcare provider may need to lower your diclofenac dosage to prevent this drug interaction from occurring.
 
Digoxin (Digitek, Lanoxicaps, Lanoxin)
Taking both digoxin and Lescol appears to slightly increase the levels of digoxin in the blood. When starting Lescol or increasing the dosage, your healthcare provider may choose to monitor you more closely and adjust your digoxin dosage as necessary.
 
Erythromycin (Ery-Tab)
Taking Lescol with erythromycin may increase your risk of dangerous side effects, including myopathy and rhabdomyolysis (see Lescol and Muscle Pain). Talk to your healthcare provider before taking these medications together.
 
Fibrates
Combining Lescol with fibrates may increase your risk of dangerous side effects, including myopathy and rhabdomyolysis (see Lescol and Muscle Pain). Talk to your healthcare provider before taking these medications together.
 
Fluconazole (Diflucan)
Fluconazole can increase the level of Lescol in your blood, possibly increasing your risk of side effects. Talk to your healthcare provider before taking these medications together.
 
Glyburide (DiaBeta, Glynase, Micronase)
Taking glyburide and Lescol together may increase the level of both medications in your blood, increasing your chance of side effects. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications as necessary.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
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