Lescol Drug Interactions

More Information on Interactions With Lescol

The following sections explain in detail the potentially negative interactions that can occur when Lescol is combined with any of the drugs listed above.
 
Colchicine
There have been reports of muscle problems in people who were taking both Lescol and colchicine. Talk to your healthcare provider before combining these medications. If you are taking these medications together, let your healthcare provider know immediately if you develop any muscle pain or weakness.
 
Cholestyramine (Questran, LoCholest, Prevalite)
Cholestyramine can bind to Lescol in your digestive tract, preventing it from being absorbed into your body. This may make Lescol less effective. In order to prevent this interaction, you should take Lescol at bedtime, at least two hours after taking cholestyramine.
 
Cimetidine (Tagamet)
Taking cimetidine and Lescol together may increase the level of Lescol in your blood, increasing your risk of Lescol side effects. Your healthcare provider may need to adjust your Lescol dosage or may recommend one of the many cimetidine alternatives.
 
In addition, both cimetidine and Lescol can decrease the level of hormones in your body. Taking them together may theoretically increase your chance of problems due to low hormones.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Taking cyclosporine and Lescol simultaneously may increase the level of Lescol in the blood. This can cause significant reactions, including increasing the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis (see Lescol and Muscle Pain). Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments.
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