When taking Juvisync, the dosage will depend on other medical conditions you have, other medications you are taking, and various other factors. This medicine comes as a tablet that is taken once daily in the evening. The recommended starting dose is typically 100/40 mg, although lower amounts may be needed if you are taking certain other medicines.
In September 2013, Merck & Co, Inc., announced that it would be discontinuing this medication. It is clear that this decision was made for business reasons, not for safety reasons.
An Introduction to Dosing With JuvisyncThe dosage of Juvisync® (sitagliptin/simvastatin) your healthcare provider recommends will vary, depending on a number of factors, including:
- How you respond to Juvisync
- Other medical conditions you may have
- Other medications you are taking (see Juvisync Drug Interactions)
- Your cholesterol goal.
As is always the case, do not adjust your dose unless specifically told to do so by your healthcare provider.
Juvisync Dosage for High CholesterolThe recommended starting dose of Juvisync for most people with high cholesterol is 100/40 mg, taken once a day in the evening. If you were already taking simvastatin, you can start at the same simvastatin dosage. For instance, if you were taking 20 mg of simvastatin, you can switch to Juvisync 100/20 mg once daily.
Some of the medications that interact with simvastatin in such a way as to require lower-than-usual Juvisync dosages include:
- Amiodarone (Cordarone®, Pacerone®)
- Amlodipine (Norvasc®)
- Diltiazem (Cardizem®, Cardizem CD®, Cardizem LA®, Cartia XT®, Dilacor XR®, Dilt-CD®, Diltia XT®, Dilt-XR®, Taztia XT®, Tiazac®)
- Dronedarone (Multaq®)
- Ranolazine (Ranexa®)
- Verapamil (Calan®, Calan® SR, Covera-HS®, Isoptin SR®, Verelan®, Verelan PM®).
(Click Juvisync Drug Interactions for more information.)
No dosage adjustment is required for people with mild kidney disease. People with moderate kidney disease need a lower-than-usual dosage of the sitagliptin component of Juvisync. For people with moderate kidney disease, Juvisync comes in strengths with half as much sitagliptin (only 50 mg, instead of 100 mg), along with the normal strengths of simvastatin (10, 20, or 40 mg). The drug is not recommended at all for people with severe kidney disease.