Juvisync and Muscle Pain

Drug Interactions

Serious muscle problems are more common when Juvisync is first started or when the dosage is increased, but it can happen at any time. There are also certain medicines that can increase the risk for serious muscle problems when taken with Juvisync. These medicines include but are not limited to:
    • Fluconazole (Diflucan®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Posaconazole (Noxafil®)
    • Voriconazole (VFEND®)
  • Certain antibiotics, such as:
  • Protease inhibitors, such as:
Grapefruit juice and grapefruit products, including grapefruit supplements, should also be avoided.
Some of these medications should not be combined with simvastatin at all, while others can be taken as long as the simvastatin dosage is reduced (see Juvisync Drug Interactions for more information).
Keep in mind that the risk for serious muscle problems increases with higher simvastatin dosages and appears to be highest in the first year of use. The highest simvastatin dosage (80 mg a day) should be reserved only for people who have already been on that dosage for a year or more without any muscle problems. For everyone else, the maximum dosage is 40 mg a day (or even less, in some situations).
Common Symptoms of Diabetic Neuropathy

Juvisync Medication Information

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