Reducing Cholesterol

Fibrates
Fibrates lower LDL somewhat, but are used mainly to treat high triglyceride and low HDL levels. When used with a statin, these cholesterol lowering medications may increase the chance of muscle problems.
 
An example of a fibrate medication used in reducing cholesterol is gemfibrozil (Lopid®).
 
Microsomal Triglyceride Transfer Protein Inhibitors
Approved in December 2012, lomitapide (Juxtapid™) is the first and only medication in this class. It is approved for a specific genetic high cholesterol disorder known as homozygous familial hypercholesterolemia (HoFH).
 
This medication may be prescribed and dispensed only by healthcare providers and pharmacies that have been specially certified to do so, due to the potentially serious risks associated with its use. In particular, lomitapide can cause serious liver problems.
 
Oligonucleotide Inhibitors
Approved in January 2013, mipomersen (Kynamro™) is the first and only medication in this class. It is approved for a specific genetic high cholesterol disorder known as homozygous familial hypercholesterolemia (HoFH). It is given as an injection just under the skin (a subcutaneous injection) once a week and is intended for use in combination with other cholesterol medications. Like many other cholesterol medications, mipomersen can cause serious liver problems, and careful monitoring of the liver (using routine blood tests) is recommended.
 

Reducing Cholesterol: Things to Remember

While cholesterol serves an important purpose in keeping the body healthy, having high levels in the blood for long periods of time can greatly increase your risk of serious medical problems, including heart disease, stroke, atherosclerosis, and other heart and blood vessel problems.
 
Reducing cholesterol is a challenge that requires both commitment and care from you and your healthcare providers. Whatever approach you take, making a lifelong commitment to this plan is a worthy goal.
 
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High Cholesterol Treatment-Overview

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