Cholesterol Lowering Drugs

Statins

Statins are the most commonly prescribed drug for lowering cholesterol. The major effect of the statins is to lower LDL (bad cholesterol) levels. They lower LDL cholesterol more than other types of cholesterol medications. The large reductions in total cholesterol and LDL cholesterol produced by these cholesterol medications have resulted in large reductions in heart attacks and heart disease-related deaths.
 
Statins inhibit an enzyme (HMG-CoA reductase) that controls the rate of cholesterol production in the body. These medications reduce cholesterol by slowing down the production of cholesterol and by increasing the liver's ability to remove the LDL cholesterol already in the blood.
 
Studies using statins have reported 20 percent to 60 percent lower LDL cholesterol levels in patients on these cholesterol lowering drugs. Statins also reduce elevated triglyceride levels and produce a modest increase in HDL cholesterol.
 
The statins are usually administered in a single dose per day. Some must be taken at bedtime, but others can be taken at any time.  
 
The statins are well tolerated by most patients, and serious statin side effects are rare. The side effects of statins usually are mild to moderate in severity and generally go away as your body adjusts. A few patients will experience:
 
 
In rare cases, a patient will develop abnormalities in blood tests of the liver. Another rare side effect of statins is muscle problems, the symptoms of which are muscle soreness, pain, and weakness. If you experience these problems, or if you have brown urine, contact your doctor right away to get blood tests for possible muscle problems.
 
Statins include:
 
  
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