Cholesterol Drugs

Cholesterol Absorption Inhibitors

These cholesterol drugs lower LDL and can be used alone or in combination with statin drugs. Cholesterol absorption inhibitors act within the intestine to block cholesterol absorption.
 
One example of cholesterol absorption inhibitors used for lowering cholesterol is ezetimibe (Zetia®).
 

Microsomal Triglyceride Transfer Protein Inhibitors

Approved in December 2012, lomitapide (Juxtapid™) is the first and only medication in this class. It is approved for a specific genetic high cholesterol disorder known as homozygous familial hypercholesterolemia (HoFH).
 
This medication may be prescribed and dispensed only by healthcare providers and pharmacies that have been specially certified to do so, due to the potentially serious risks associated with its use. In particular, lomitapide can cause serious liver problems. It also has several significant drug interactions, and dosing is not particularly straightforward (people must start with a low dosage and gradually increase to a higher one).
 

Oligonucleotide Inhibitors

Approved in January 2013, mipomersen (Kynamro™) is the first and only medication in this class. It is approved for a specific genetic high cholesterol disorder known as homozygous familial hypercholesterolemia (HoFH). It is given as an injection just under the skin (a subcutaneous injection) once a week and is intended for use in combination with other cholesterol medications. Like many other cholesterol medications, mipomersen can cause serious liver problems, and careful monitoring of the liver (using routine blood tests) is recommended.
 
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