Drug Interactions With Fenofibrate

More Information on Interactions With Fenofibrate

The following sections provide more detailed information on how specific drugs interact with fenofibrate.
Fenofibrate can increase the anticoagulant effect of warfarin. This means that you are at an increased risk of bleeding if you are taking both fenofibrate and warfarin. Your healthcare provider may choose to monitor your INR and prothrombin time more frequently and make any necessary dosing adjustments if this is the case.
HMG-CoA Reductase Inhibitors
The use of fenofibrate with a statin medication may increase the risk of kidney and muscle problems. This combination should only be used if the benefit of further lowering cholesterol levels outweighs the risks.
Cyclosporine can make it harder for fenofibrate to be eliminated from the body. If you are taking both fenofibrate and cyclosporine, you may be at increased risk for developing kidney problems (especially if you have kidney disease). Your healthcare provider may choose to monitor your progress more closely and make any necessary dosing adjustments.
Taking fenofibrate with colchicine may increase the risk of serious problems, including serious breakdown of muscle (rhabdomyolysis). In many cases, though, the benefits of taking fenofibrate with colchicine will outweigh the possible risks. Discuss these risks and benefits for your particular situation with your healthcare provider.
Bile Acid Sequestrants
Bile acid sequestrants can bind to fenofibrate in the digestive tract and decrease its absorption into the body. Fenofibrate should be taken at least one hour before or four to six hours after a bile acid sequestrant has been given to avoid this drug interaction.
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