Drug Interactions With Fenofibrate (Cont.)

 
Warfarin
Fenofibrate can increase the anticoagulant effect of warfarin. This means that you are at an increased risk of bleeding if you are taking both fenofibrate and warfarin. Your healthcare provider may choose to monitor your INR and prothrombin time more frequently and make any necessary dosing adjustments if this is the case.
 
HMG-CoA Reductase Inhibitors
The use of fenofibrate with a statin medication should generally be avoided due to the increased risk of kidney and muscle problems. This combination should only be used if the benefit of further lowering cholesterol levels outweighs the risk.
 
Cyclosporine
Cyclosporine can make it harder for fenofibrate to be eliminated from the body. If you are taking both fenofibrate and cyclosporine, you may be at increased risk for developing kidney problems (especially if you have kidney disease). Your healthcare provider may choose to monitor your progress more closely and make any necessary dosing adjustments.
 
Bile Acid Sequestrants
Bile acid sequestrants can bind to fenofibrate in the digestive tract and decrease its absorption into the body. Fenofibrate should be taken at least one hour before or four to six hours after a bile acid sequestrant has been given to avoid this drug interaction.
 

Drug Interactions With Fenofibrate: Final Thoughts

It is possible that not all drug interactions with fenofibrate were discussed in this article. Therefore, you should talk with your pharmacist or doctor about any specific drug interactions that may apply to you.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;