Crestor vs. Lipitor

Many people may wonder what the difference is between Lipitor versus Crestor. While both medications are statins and are effective for lowering cholesterol, there are some differences. Lipitor is known to interact with grapefruit juice, but there are no dietary restrictions for Crestor. One short study showed that Crestor was more effective than Lipitor, but more research is needed to confirm these findings.

Comparing Lipitor and Crestor: An Overview

Lipitor® (atorvastatin calcium) and Crestor® (rosuvastatin calcium) are both cholesterol medications. They are quite similar in many aspects; however, there are a few important differences between the two medications.

Crestor Versus Lipitor: The Similarities

Both Crestor and Lipitor belong to a class of drugs called statins (also known as HMG-CoA reductase inhibitors). Statins work by blocking a particular enzyme, HMG-CoA reductase, that controls the rate of cholesterol production in the body. This causes the liver to make less cholesterol. Both medications are very effective for lowering cholesterol.
Crestor side effects and Lipitor side effects are similar, and both medications carry similar warnings and precautions (see Crestor Precautions and Warnings and Lipitor Precautions and Warnings). In addition, both drugs should not be taken during pregnancy.
Both drugs are approved to treat high cholesterol, high triglycerides, and low HDL cholesterol ("good" cholesterol). Both are also approved to prevent heart attacks, strokes, and certain heart procedures (such as bypass surgery) in people who do not yet have heart disease but who have certain risk factors for heart disease.
Both medications are currently available only in brand-name form, although it is very likely that Lipitor will "go generic" before Crestor, since Lipitor is an older medication.
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