Crestor Drug Interactions
Taking Crestor with a protease inhibitor may increase the level of Crestor in your blood. This can increase your risk of Crestor side effects, including serious muscle problems, such as myopathy or rhabdomyolysis (see Crestor and Muscle Pain). Your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments.
Not all protease inhibitors interact with Crestor in a significant manner. Protease inhibitor combinations that include ritonavir seem to be most likely to interact with Crestor. In particular, the combinations of atazanavir and ritonavir or lopinavir and ritonavir are likely to interact, and the maximum recommended Crestor dosage for people taking such medications is 10 mg daily.
Red Yeast Rice
Red yeast rice is a supplement used to lower cholesterol. Taking it with Crestor may increase your risk of serious muscle problems, such as myopathy or rhabdomyolysis (see Crestor and Muscle Pain). In general, you should not use Crestor with red yeast rice.
Theoretically, Crestor may decrease the level of steroid hormones in the body. Since spironolactone can also lower these hormone levels, taking these medications together may increase your risk of related problems. Talk to your healthcare provider before combining spironolactone with Crestor.
Taking Crestor and warfarin together may increase your risk of bleeding. When starting Crestor therapy or changing your Crestor dosing, your healthcare provider may choose to monitor your INR (the results of a blood-clotting test) more closely and make any necessary adjustments.