Crestor Drug Interactions
Taking a fibrate and Crestor at the same time may increase the level of Crestor in your blood. This can increase your risk of Crestor side effects, including serious muscle problems, such as myopathy or rhabdomyolysis (see Crestor and Muscle Pain). In general, Crestor should not be taken with a fibrate. However, if your healthcare provider recommends taking these medications together, the maximum recommended dose of Crestor is lower than usual (10 mg per day).
Theoretically, Crestor may decrease the level of steroid hormones in the body. Since ketoconazole can also lower these hormone levels, taking these medications together may increase your risk of related problems. Talk to your healthcare provider before combining ketoconazole with Crestor.
Combining niacin with Crestor may increase the risk of serious muscle problems, such as myopathy or rhabdomyolysis (see Crestor and Muscle Pain). Do not combine these medications without your healthcare provider's approval.