Crestor^® (rosuvastatin calcium) is a prescription medicine used to treat high cholesterol. In addition to lowering total cholesterol and LDL cholesterol (bad cholesterol), the drug can raise HDL cholesterol (good cholesterol) and lower triglycerides. The drug's effects help reduce the risk of developing problems related to high cholesterol, such as heart disease or a heart attack. A few side effects of Crestor include muscle pain, constipation, nausea, and weakness. Among the conditions you should tell your healthcare provider about before you take Crestor are heart disease, diabetes, and liver disease or liver failure. To reduce the chances of drug interactions, you should also let your healthcare provider know about all of the medicines you currently take.