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Drug Interactions With Cholestyramine
When certain medicines are taken together, there is a possibility of creating negative drug interactions. With Cholestyramine, drug interactions may occur if it is mixed with medications such as thyroid medicines, oral phosphate supplements, or propranolol. If the combination of drugs binds together in the intestines, they may not get completely absorbed into your system. Cholestyramine drug interactions may be avoided if taken an hour before taking Cholestyramine.
Cholestyramine has the potential to interact with a number of other medications. Some of these drug interactions with Cholestyramine include:
- Warfarin (Coumadin®, Jantoven®)
- Thiazide diuretics
- Propranolol (Inderal®)
- Tetracycline (Sumycin®, Achromycin®, Wesmycin®)
- Penicillin G (Bicillin®, Pfizerpen®, Wycillin®)
- Phenobarbital (Solfoton®)
- Thyroid medicines
- Estrogens and progestins
- Digoxin (Digitek®, Lanoxin®, Lanoxicap®)
- Oral phosphate supplements
- Vitamin K products or phytonadione (Mephyton®)
- Ursodiol (Actigall®)
- Ezetimibe (Zetia®).
Warfarin
Cholestyramine may bind with warfarin in the intestines, preventing it from getting completely absorbed into the body. You can prevent this by taking warfarin at least one hour before or four to six hours after you take your Cholestyramine.
Thiazide Diuretics
Cholestyramine may bind with a thiazide diuretic in the intestines, preventing it from getting completely absorbed into the body. You can prevent this by taking a thiazide diuretic at least one hour before or four to six hours after you take your Cholestyramine.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD