Altoprev Drug Interactions

Altoprev drug interactions can produce serious muscle problems, such as myopathy and rhabdomyolysis. Medications like erythromycin, clarithromycin, and HIV protease inhibitors should not be taken along with Altoprev unless the benefits outweigh the risk of interactions. If you are taking Altoprev, avoid eating grapefruit or grapefruit products, which increase the level of Altoprev in the blood, and tell your healthcare provider immediately about any unexplained muscle pain, tenderness, or weakness.

Altoprev Drug Interactions: An Introduction

Altoprev® (lovastatin extended-release) can potentially interact with a number of other medicines. Some possible Altoprev interactions can include:



  • Certain antifungals, such as:


    • Fluconazole (Diflucan®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Posaconazole (Noxafil®)
    • Voriconazole (Vfend®)


  • Grapefruit juice
  • Nefazodone (Serzone®)
  • Niacin (nicotinic acid, Niacor®, Nicolar®)
  • Protease inhibitors, such as:


Some of these drug interactions with Altoprev may increase your risk for developing serious muscle problems (see Altoprev and Muscle Pain). If you experience unexplained muscle pain, tenderness, or weakness while taking Altoprev (especially if you also have a fever or feel ill), it is important to contact your healthcare provider right away.
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Altoprev Medicine

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