Altoprev Drug Interactions

Diltiazem
Taking both diltiazem and Altoprev together may increase the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments. If you take diltiazem, the recommended starting Altoprev dosage is 10 mg daily, and the maximum recommended dosage is 20 mg daily.
 
Fibrates
Combining a fibrate with Altoprev increases the risk of serious muscle problems. Combining Altoprev with gemfibrozil should be avoided. Combining Altoprev with other fibrates should be done cautiously with extra monitoring.
 
Danazol
Taking danazol and Altoprev together may increase the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments. If you take danazol, the recommended maximum dosage is 20 mg daily.
 
Grapefruit
People on Altoprev should not drink grapefruit juice, eat grapefruit, or use grapefruit supplements because it can increase the levels of medication in the blood. This can increase the chances for developing a serious muscle problem (myopathy or rhabdomyolysis), which can cause the kidneys to stop working (see Altoprev and Muscle Pain).
 
If you are being treated with Altoprev and want to continue drinking grapefruit juice, talk to your healthcare provider about other cholesterol medications that you can take.
 
Niacin
Both niacin and Altoprev alone can increase the chances for developing serious muscle problems. Therefore, combining these medicines may pose an even greater risk. If you are taking Altoprev and niacin, your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments. The dose of Altoprev should not exceed 20 mg per day.
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